Predictive Role of Haematological Determinants on Outcomes of Critically Ill COVID-19 Patients Admitted to Intensive Care Unit

Background: The mortality of patients admitted to the intensive care unit (ICU) with COVID-19 remains significantly high. Severe pneumonia is characterised by refractory hypoxemia significant shunting due a combination alveolar damage, vascular vasoconstriction, and occlusion microthrombi. Similar pathological features are seen in extra-pulmonary organs. However, influence thrombotic markers on risk mechanical ventilation (MV) development acute kidney injury (AKI) not fully defined. Methods: This was cross-sectional evaluation haemostatic ICU determine their predictability for thromboembolism need non-invasive or invasive MV, AKI, mortality. Results: An extended coagulation profile obtained 71 SARS-CoV-2 positive ICU. All had severe hypoxic respiratory failure required MV. There were increases peak D-dimer (3.0 mg/L), factor VIII levels (255 IU/dL) vWF antigen (471 low ADAMTS13 activity (54.7 compared reference ranges. Peak consistently raised who developed AKI ADAMTS13/vWF/platelet axis associated disease severity, multi-organ dysfunction, Conclusions: Haematological abnormalities common feature pneumonia. We found vWF-ADAMTS13-platelet increased severity outcome Larger studies needed evaluate this more comprehensively.